-Secretase Modulators: Can We Combine Potency with Safety?
نویسندگان
چکیده
منابع مشابه
γ-Secretase Modulators: Can We Combine Potency with Safety?
γ-Secretase modulation has been proposed as a potential disease modifying anti-Alzheimer's approach. γ-Secretase modulators (GSMs) cause a product shift from the longer amyloid-beta (Aβ) peptide isoforms to shorter, more soluble, and less amyloidogenic isoforms, without inhibiting APP or Notch proteolytic processing. As such, modulating γ-secretase may avoid some of the adverse effects observed...
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ژورنال
عنوان ژورنال: International Journal of Alzheimer's Disease
سال: 2012
ISSN: 2090-8024,2090-0252
DOI: 10.1155/2012/295207